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Literature summary extracted from

  • Oliva, M.L.; Santomauro-Vaz, E.M.; Andrade, S.A.; Juliano, M.A.; Pott, V.J.; Sampaio, M.U.; Sampaio, C.A.
    Synthetic peptides and fluorogenic substrates related to the reactive site sequence of Kunitz-type inhibitors isolated from Bauhinia: interaction with human plasma kallikrein (2001), Biol. Chem., 382, 109-113.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.34 Bauhinia ungulata factor Xa inhibitor protein
-
 Homo sapiens
3.4.21.34 Bauhinia variegata trypsin inhibitor protein
-
 Homo sapiens
3.4.21.34 o-aminobenzoyl-FESPLRINIIKE-N-(2,4-dinitrophenyl)-ethylene diamine competitive inhibitors, based on the Bauhinia bauhinioides inhibitor protein reactive site sequence Homo sapiens
3.4.21.34 o-aminobenzoyl-RPGLPVRFESPL-N-(2,4-dinitrophenyl)-ethylene diamine competitive inhibitors, based on the Bauhinia bauhinioides inhibitor protein reactive site sequence Homo sapiens
3.4.21.34 specific serine protease inhibitor protein from Bauhinia bauhinioides seeds Kunitz type, purified 20 kDa protein Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.34 0.00043
-
 o-aminobenzoyl-VMIAALPRTMFIQ-N-(2,4-dinitrophenyl)-ethylene diamine pH 8.0, 37°C Homo sapiens
3.4.21.34 0.00142
-
 o-aminobenzoyl-VVISALPRTMFIQ-N-(2,4-dinitrophenyl)-ethylene diamine pH 8.0, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.34 soluble plasma Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.34 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.34 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.34 kininogen + H2O
-
 Homo sapiens bradykinin + fragment of kininogen
-
 ?
3.4.21.34 additional information no activity with o-aminobenzoyl-RPGLPVRFESPL-N-(2,4-dinitrophenyl)-ethylene diamine and o-aminobenzoyl-FESPLRINIIKE-N-(2,4-dinitrophenyl)-ethylene diamine, which are based on the Bauhinia bauhinioides inhibitor protein reactive site sequence Homo sapiens ?
-
 ?
3.4.21.34 o-aminobenzoyl-VMIAALPRTMFIQ-N-(2,4-dinitrophenyl)-ethylene diamine + H2O low activity, substrate sequence is based on the Bauhinia ungulata inhibitor protein reactive site sequence Homo sapiens ?
-
 ?
3.4.21.34 o-aminobenzoyl-VVISALPRTMFIQ-N-(2,4-dinitrophenyl)-ethylene diamine + H2O substrate sequence is based on the Bauhinia variegata inhibitor protein reactive site sequence Homo sapiens ?
-
 ?
3.4.21.34 RPGLPVRFESPLRINIIKE + H2O peptide based on the reactive site of the Bauhinia bauhinioides inhibitor protein, similar to the kinin moiety in human kininogen Homo sapiens RPGLPVRFESPLR + INIIKE main products ir
3.4.21.34 RPGLPVRFESPLRINIIKE + H2O peptide based on the reactive site of the Bauhinia bauhinioides inhibitor protein, similar to the kinin moiety in human kininogen Homo sapiens RPGLPVR + FESPLRINIIKE
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.34 37
-
 assay at Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.34 0.01
-
 o-aminobenzoyl-VMIAALPRTMFIQ-N-(2,4-dinitrophenyl)-ethylene diamine pH 8.0, 37°C Homo sapiens
3.4.21.34 3.13
-
 o-aminobenzoyl-VVISALPRTMFIQ-N-(2,4-dinitrophenyl)-ethylene diamine pH 8.0, 37°C Homo sapiens
3.4.21.34 3.66
-
 o-aminobenzoyl-VVISALPRTMFIQ-N-(2,4-dinitrophenyl)-ethylene diamine pH 8.0, 37°C Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.34 8
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.34 0.00000035
-
 specific serine protease inhibitor protein from Bauhinia bauhinoides seeds pH 8.0, 37°C Homo sapiens
3.4.21.34 0.0000069
-
 Bauhinia ungulata factor Xa inhibitor protein pH 8.0, 37°C Homo sapiens
3.4.21.34 0.000023
-
 Bauhinia variegata trypsin inhibitor protein pH 8.0, 37°C Homo sapiens